The role of ultrasonographic hepatic artery resistive index in the diagnosis of insulin resistance in obese children with non-alcoholic fatty liver disease Non-alkolik yaǧli karaciǧer hastaliǧi olan obez çocuklarda insulin rezistansinin belirlenmesinde ultrasonografik hepatik arter rezistif indeksinin rolü

Hizli Ş., Koçyiǧit A., Arslan N., Tuncel S., Demircioǧlu F., Çakmakçi H., ...More

Turkish Journal of Medical Sciences, vol.40, no.3, pp.335-342, 2010 (SCI-Expanded) identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 3
  • Publication Date: 2010
  • Doi Number: 10.3906/sag-0906-22
  • Journal Name: Turkish Journal of Medical Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.335-342
  • Ankara Yıldırım Beyazıt University Affiliated: Yes


Aim: To determine the role of hepatic artery resistive index (HARI) measurement in the prediction of insulin resistance (IR) in obese children with nonalcoholic fatty liver disease (NAFLD). Materials and methods: A total of 64 obese subjects with NAFLD (13.5 ± 1.36 years of age, 34 male) and 32 age-and gender-matched control subjects (13.8 ± 1.24 years of age, 16 male) were enrolled in the study. All subjects underwent a physical examination, laboratory tests, and ultrasonographic and Doppler examinations of the liver. The homeostasis model assessment of IR (HOMA-IR) was used for the IR diagnosis. Results: Obese subjects with NAFLD had significantly higher HARI, insulin, alanine aminotransferase (ALT), total cholesterol (TC), triglycerides (TG), and HOMA-IR than the control subjects. Obese subjects with NAFLD and IR had significantly higher HARI compared to obese subjects with NAFLD but without IR (0.761 ± 0.04 vs. 0.732 ± 0.04, P = 0.006). Changes in HARI correlated significantly to changes in BMI, SDS-BMI, MAC, TSF, MAC, ALT, TC, insulin, and HOMA-IR (r = 0.578, P = 0.001; r = 0.547, P = 0.001; r = 0.549, P = 0.001; r = 0.504, P = 0.001; r = 0.549, P = 0.001; r = 0.223, P = 0.029; r = 0.306, P = 0.002; r = 0.315, P = 0.011; r = 0.295, P = 0.018, respectively). As an optimal cutoff point, a HARI level of 0.715 determined IR with 81.2% sensitivity and 71.9% specificity. Conclusion: Our findings suggest that HARI might be used as a simple and non-invasive screening method to predict IR in obese children with NAFLD. © TÜBİTAK.