Grup B Streptokok Enfeksiyonlarında Hastaya Ait Demografik ve Klinik Veriler ile Antibiyotik Duyarlılık Sonuçlarının Değerlendirilmesi

Tuğcan BAŞYİĞİT

Grup B Streptokok Enfeksiyonlarında Hastaya Ait Demografik ve Klinik Veriler ile Antibiyotik Duyarlılık Sonuçlarının Değerlendirilmesi

Tezin Türü: Tıpta Uzmanlık

Tezin Yürütüldüğü Kurum: Ankara Yıldırım Beyazıt Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri, Türkiye

Tezin Onay Tarihi: 2020

Tezin Dili: Türkçe

Öğrenci: Tuğcan BAŞYİĞİT

Danışman: TUBA DAL

Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu

Özet:

Group B streptococci (GBS) are considered as an important public health problem due to neonatal and invasive infections they cause. Demographic screening of patients and determining antibiotic susceptibility profiles of GBS isolates will provide useful information for prevention and treatment of those infections. In this study, it was aimed to retrospectively evaluate the demografic and clinical data of 89 patients who admitted to Ankara City Hospital between 2019-2020, and to determine antimicrobial susceptibility profiles of GBS isolates that obtained from their samples. Sixty-one (61%) of the patients were female and twenty-eight (31%) of the patients were male. The samples that obtained from those patients were urine (43%), wound (23%), vaginal swab (16%), DTA (5%), tissue (2%), blood (2%), BAL (1%) and synovial fluid (1%). Fourty-three (48%) of the patients had underlying conditions for GBS infection/colonization which were diabetes (11%), hypertension (8%), atherosclerotic heart diseases (6%), neoplasms (5%) and other diseases. The average age was 44 ± 13 in female patients, 52 ± 12 in male patients and 47 ± 13 in all patients. Percentage of GBS growth in female patients was higher than male patients (p<0.05). The antibiotics with the highest resistance observed were tetracycline (86%), levofloxacin (44%) and erythromycin (44%). Erythromycin resistance seen in levofloxacin resistant isolates was statistically significant, compared to levofloxacin susceptible isolates (p<0.05). There are studies reporting reduced penicillin susceptibility and macrolide resistance in fluoroquinolone resistant isolates. Further studies are required to determine the mechanisms of erythromycin resistance observed with levofloxacin resistance and to accurately detect reduced penicillin susceptibility.