An Unusual Trigger for Cutaneous Mastocytosis: The Insulin Pump
Astim Allerji Immunoloji, cilt.15, ss.55-59, 2017 (Hakemli Dergi)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 15
- Basım Tarihi: 2017
- Doi Numarası: 10.21911/aai.5027
- Dergi Adı: Astim Allerji Immunoloji
- Sayfa Sayıları: ss.55-59
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Mastocytosis is a relatively infrequent disorder characterized by
mast cell proliferation within primarily the skin, but also various
organs such as the bone marrow, liver, spleen, lymph nodes and
the gastrointestinal system. Several factors are known to induce
symptoms in patients with mastocytosis. A 13-year-old boy with
cutaneous mastocytosis and type 1 diabetes mellitus developed
multiple itchy papules 2 to 3 days after he started receiving insulin
(lispro) pump therapy. Punch biopsy revealed widespread mast
cell infiltration on the papillary dermis. We hypothesized that the
insulin pump catheter caused a physical stimulus due to local microtrauma and resulted in the formation of the lesions. We, therefore,
discontinued insulin pump treatment and switched to SC insulin
therapy. While previous lesions healed successfully, no new lesions
occurred. To confirm our hypothesis, we repeated the procedure
and observed the occurrence of similar lesions around the insulin
pump catheter. Herein, we present for the first time, a patient with
type 1 diabetes mellitus and cutaneous mastocytosis who developed
exacerbation of lesions during insulin pump therapy.