The role of oxidative stress markers in the pathophysiology of migraine and after treatment
Neurosurgery Quarterly, cilt.24, sa.4, ss.286-290, 2014 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 24 Sayı: 4
- Basım Tarihi: 2014
- Doi Numarası: 10.1097/wnq.0b013e3182a2fca3
- Dergi Adı: Neurosurgery Quarterly
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.286-290
- Anahtar Kelimeler: Antioxidants, Migraine, Oxidative stress, Oxidative Stress Index, Visual Analog Pain Scale
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Introduction: In this study, we investigated whether oxidant and antioxidant levels have a role in the pathophysiology of migraine and whether these measurements can be used effectively in the follow-up treatment. Materials and Methods: Thirty-one patients were admitted to the emergency department because of migraine attack and 30 healthy volunteers were enrolled in the study. The treatment was initiated with metoclopramide, and total antioxidant status (TAS), thiol, paraoxonase (PON), stimulated paraoxonase (St PON), arylesterase (ARE), and total oxidant status (TOS) were evaluated with the samples that were collected at the time of admission and at 30th and 60th minutes. Oxidative Stress Index (OSI) was calculated. Intensity of pain was assessed by the Visual Analogue Scale (VAS), simultaneously with sample collection. The results of patients were compared with those of healthy volunteers. Results: In the samples of patients collected at the time of admission, thiol and ARE levels were significantly low (226.6 ± 29 vs. 170.2 ± 52.2, P = 0.000 and 339.3 ± 47.9 vs. 278.0 ± 44.8, P = 0.000) and TOS and OSI were significantly high (2.1 ± 0.5 vs. 3.0 ± 1.8, P = 0.000 and 1.1 ± 0.3 vs. 1.6 ± 1.0, P = 0.000) when compared with the control group. There was no significant change in the levels of TAS, PON, and St PON (1.9 ± 0.3 vs. 1.8 ± 0.3, P = 0153 and 210.5 ± 135.9 vs. 164.5 ± 101.6, P = 0139 and 512.5 ± 353.3 vs. 419.8 ± 276.5, P = 0.262). VAS scores at 30th and 60th minutes were significantly decreased when compared with those at the time of admission. However, there was no correlation between the decrease in VAS score and TAS, thiol, PON, St PON, ARE, and TOS and OSI levels (P >0.05). Conclusions: The effect of oxidative stress in the pathophysiology of migraine is more likely to be an oxidant. These parameters alone are not sufficient to explain the pathophysiology of migraine because no significant changes were observed in either of antioxidant and oxidant levels, whereas a significant improvement in pain was achieved after the treatment of patients. Therefore, these results suggest that there are more than one mechanism in the pathophysiology of migraine.