Dynamic Thiol/Disulphide Homeostasis in Children and Adolescents with Non-Autoimmune Subclinical Hypothyroidism


Ucakturk S. A. , Alisik M., Ugur C., Elmaogullari S., Mengen E., EREL Ö.

MEDICAL PRINCIPLES AND PRACTICE, cilt.27, ss.44-48, 2018 (SCI İndekslerine Giren Dergi)

  • Cilt numarası: 27 Konu: 1
  • Basım Tarihi: 2018
  • Doi Numarası: 10.1159/000487138
  • Dergi Adı: MEDICAL PRINCIPLES AND PRACTICE
  • Sayfa Sayısı: ss.44-48

Özet

Objective: To evaluate the thiol/disulphide homeostasis in children with non-autoimmune subclinical hypothyroidism (SHT). Subjects and Methods: Thiol/disulphide homeostasis, involving native thiol (SH), disulphide (SS), and total thiol (SS + SH), was evaluated in 60 children and adolescents who were negative for thyroid auto-antibodies (anti-thyroid peroxidase, anti-thyroglobulin) and had a thyroid-stimulating hormone (TSH) value of > 5 mIU/L, and in 40 sex-and age-matched healthy control subjects who were negative for thyroid autoantibodies and had normal TSH levels. Lipid profiles and urine iodine levels were also determined. Results: SH (466 +/- 32.8 vs. 462 +/- 32.1 mu mol/L p = 0.59), SH + SS (508 +/- 34.0 vs. 506 +/- 32.7 mu mol/L, p = 0.81), SS (21 +/- 5.5 vs. 22 +/- 5.8 mu mol/L, p = 0.41), SS/SH (4.5 +/- 1.2 vs. 4.8 +/- 1.3%, p = 0.36), SS/SH + SS (4.1 +/- 1.0 vs. 4.3 +/- 1.1%, p = 0.36) and SH/SH + SS (91 +/- 2.1 vs. 91 +/- 2.1%, p = 0.31) levels were similar in children with SHT and control subjects (p > 0.05). There was no difference between total cholesterol, triglyceride, and low-density lipoprotein levels in SHT patients and controls. No difference was detected between the patients with or without iodine deficiency in the SHT group in terms of thiol/disulphide homeostasis parameters. Conclusion: The status of dynamic thiol/disulphide homeostasis did not change in children and adolescents with non-autoimmune SHT. Future studies are needed for the evaluation of oxidative stress in patients with long-standing non-autoimmune SHT. (C) 2018 The Author(s) Published by S. Karger AG, Basel