Elevated neuron specific enolase levels in post-traumatic stress disorder

UYSAL M., CEYLAN M. F., TURAL HESAPÇIOĞLU S.

European Journal of Pediatrics, vol.184, no.1, 2025 (SCI-Expanded, Scopus) identifier identifier

  • Publication Type: Article / Article
  • Volume: 184 Issue: 1
  • Publication Date: 2025
  • Doi Number: 10.1007/s00431-024-05889-6
  • Journal Name: European Journal of Pediatrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, BIOSIS, CAB Abstracts, CINAHL, EMBASE
  • Keywords: Major depressive disorder, Neuronal damage, Neuronal pathology, NSE, PTSD
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Neuron-specific enolase (NSE) is a biomarker indicative of neuronal cell damage. The aim of this study is to assess the NSE levels in patients diagnosed with post-traumatic stress disorder (PTSD) and major depressive disorder (MDD). Blood samples were collected from 43 individuals with PTSD (age range 11–17), 43 individuals with MDD (age range 10–17), and 40 age- and gender-matched healthy controls. The NSE levels were analyzed, and participants completed the Post-traumatic Stress Reaction Index, the Children’s Depression Inventory, and the Screen for Child Anxiety Related Disorders. Additionally, the Clinical Global Impressions Scale was filled out by the researcher. Results indicated that the NSE levels in the PTSD group were significantly higher than those in both the MDD group and the healthy control group. No significant difference in NSE levels was observed between the MDD group and the healthy control group. Conclusions: The findings suggest that elevated NSE levels in PTSD may be indicative of stress-related neuronal damage, distinguishing PTSD from MDD and healthy controls. These results underline the need for further research to explore the potential of NSE as a biomarker for PTSD and its implications for diagnosis and intervention strategies. (Table presented.)