External quality control of Mycobacterium tuberculosis drug susceptibility testing: Results of two rounds in endemic countries

Fattorini L., Iona E., Cirillo D., Migliori G., Orefici G., Aziz M., ...Daha Fazla

International Journal of Tuberculosis and Lung Disease, cilt.12, sa.2, ss.214-217, 2008 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

  • Yayın Türü: Makale / Tam Makale
  • Cilt numarası: 12 Konu: 2
  • Basım Tarihi: 2008
  • Dergi Adı: International Journal of Tuberculosis and Lung Disease
  • Sayfa Sayıları: ss.214-217


SETTING: Quality assurance for the World Health Organization (WHO)/International Union Against Tuberculosis and Lung Disease (The Union) global tuberculosis (TB) drug resistance surveillance programme. OBJECTIVE: To monitor the quality of drug susceptibility testing (DST) in different countries. METHODS: In 2002-2003 and 2005-2006, 20 Mycobacterium tuberculosis strains were sent by the WHO/Union Supranational Reference Laboratory of Rome to TB reference laboratories in Albania, Bahrain, Kosovo, Mozambique, Oman, Qatar and Turkey for external quality control (EQC). RESULTS: In 2002-2003, the specificity, sensitivity, efficiency, reproducibility and predictive values for resistance/susceptibility were ≥90% for streptomycin (SM), isoniazid (INH) and ethambutol (EMB). In 2005-2006, all statistical values were ≥96% for SM, INH, rifampicin and EMB. CONCLUSION: EQC improved the quality of M. tuberculosis DST in the participating countries. © 2008 The Union.