Oxidative stress and thiol/disulfide homeostasis in human papillomavirus infections
Indian Journal of Dermatology, cilt.67, sa.3, ss.228-231, 2022 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 67 Sayı: 3
- Basım Tarihi: 2022
- Doi Numarası: 10.4103/ijd.ijd_797_20
- Dergi Adı: Indian Journal of Dermatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EMBASE, Veterinary Science Database, Directory of Open Access Journals
- Sayfa Sayıları: ss.228-231
- Anahtar Kelimeler: Human papillomavirus infection, oxidative stress, thiol, disulfide homeostasis, thiols, viral warts
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
© 2022 Wolters Kluwer Medknow Publications. All rights reserved.Introduction: Viral warts are a group of dermatological diseases caused by human papillomavirus (HPV). Several studies have demonstrated an association between HPV infections and oxidative stress. Thiols are important components of cellular redox homeostasis as antioxidant molecules in the organism. Aim: This study aimed to investigate the role of oxidative stress in patients with HPV infection by analyzing native thiol/disulfide homeostasis. Material and Methods: Forty-Two patients with HPV infection and 40 healthy subjects were analyzed for the levels of native thiols, total thiols, and disulfide. Disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol ratios were also calculated. Results: Disulfide and total thiol levels were higher in the patients compared to the healthy controls. The disulfide/native thiol ratio was also higher in the patient group. Native and total thiol levels decreased with the increasing duration of the disease. Conclusion: The native thiol/disulfide homeostasis was shifted toward disulfide in the patients' group, indicating the existence of oxidative stress in HPV infection.