The effect of oxidative stress on the etiopathogenesis of primary dysmenorrhea

ABSTRACT

Aim:The aim of this research is to investigate the effect of oxidative stress on the

etiopathogenesis of primary dysmenorrhea by comparing serum oxidative stress

markers and antioxidant enzyme levels

Methods:A total of 38 women with primary dysmenorrhea and 21 women without

dysmenorrhea who applied to our hospital’s gynecology clinic were included in the

study. Two blood samples were taken from each of the women included in the study,

on the 3rd day and the 21st day of their menstrual cycle. The serum levels of Paraoxonase

(PON), Arylesterase (ARES), and Stimulated Paraoxonase (SPON) were

examined. PON, ARES, and SPON levels were compared between the patient and

control groups, as well as within each group, on the 3rd and 21st days of menstrual

cycles.

Results: In our study, a significant difference was found in the mean age between the

patient and control groups. No significant differences were observed in terms of age

at menarche, regularity, and duration. No significant differences were found in the

ARES, PON, and SPON levels examined on the 3rd and 21st days of the menstrual

cycle between the patient and control groups.

Conclusion:According to the results of our study, there was no significant difference

in the levels of these markers between the patient and control groups on their respective

menstrual cycle days. Based on this, we believe that oxidative and antioxidant

markers are not directly involved in the etiopathogenesis of dysmenorrhea or they

exhibit cycle-independent effects.

Keywords: Dysmenorrhea, Oxidative Stress, Paraoxonase, Arylesterase