Oxidative–Antioxidative Markers in Pregnant Women with Fetal Neural Tube Defects

Özyer S., Ozel S., KARABULUT E. , Kahyaoglu S., NEŞELİOĞLU S. , EREL Ö. , ...More

Fetal and Pediatric Pathology, vol.40, no.2, pp.93-102, 2021 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 40 Issue: 2
  • Publication Date: 2021
  • Doi Number: 10.1080/15513815.2019.1686783
  • Title of Journal : Fetal and Pediatric Pathology
  • Page Numbers: pp.93-102


© 2019 Taylor & Francis Group, LLC.Objective: We compared markers of oxidative stress (OS) in mothers with and without fetal neural tube defects (NTDs). Methods: Pregnant mothers in the second trimester with NTD-affected fetuses and age, gestational age, and body mass index-matched control mothers with unaffected fetuses were included. Maternal serum thiol-disulfide homeostasis parameters and ischemia-modified albumin (IMA) were measured. Results: In 30 affected mothers compared to 31 controls, disulfide levels, disulfide/native thiol, and disulfide/total thiol ratios were higher; native and total thiol levels and native thiol/total thiol ratios were lower (p < 0.001). Mothers with NTD-affected fetuses had higher levels of IMA than controls (p = 0.025). Conclusion: The thiol-disulfide homeostasis balance was shifted in favor of disulfide, suggesting increased thiol oxidation and OS in the second trimester of NTD-affected pregnancies. Maternal levels of IMA, an oxidatively altered form of albumin, thus a measure of OS, were higher in NTD-affected second trimester pregnancies compared to controls.