Hyperthermia and radiotherapy combination for locoregional recurrences of breast cancer: a review

Arslan S. A., Ozdemir N., ŞENDUR M. A. N., Eren T., Ozturk H. F., Aral I. P., ...More

BREAST CANCER MANAGEMENT, vol.6, no.4, pp.117-126, 2017 (ESCI) identifier

  • Publication Type: Article / Review
  • Volume: 6 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.2217/bmt-2017-0011
  • Journal Indexes: Emerging Sources Citation Index (ESCI)
  • Page Numbers: pp.117-126
  • Ankara Yıldırım Beyazıt University Affiliated: Yes


Breast cancer is a second common form of malignancy and is one of the leading causes of mortality among cancer patients across the world. Locoregional recurrence occurs in 5-20% of patients despite upfront treatment. Local therapy (surgery plus minus re-irradiation) with or without systemic therapy is generally recommended for management. Local control rates vary; months to years, but a significant percentage lives 5 years. Therefore, treatment strategies to increase response rates are significant. Hyperthermia is one of the most potent radiosensitizers and data from meta-analysis and randomized trials support its use with radiotherapy. This study reviews the biologic rationale and clinical evidence about concomitant use of hyperthermia and radiotherapy in locally-recurrent breast cancer patients.