Hyperthermia and radiotherapy combination for locoregional recurrences of breast cancer: a review


Arslan S. A. , Ozdemir N., ŞENDUR M. A. N. , Eren T., Ozturk H. F. , Aral I. P. , ...More

BREAST CANCER MANAGEMENT, vol.6, no.4, pp.117-126, 2017 (Journal Indexed in ESCI) identifier

  • Publication Type: Article / Review
  • Volume: 6 Issue: 4
  • Publication Date: 2017
  • Doi Number: 10.2217/bmt-2017-0011
  • Title of Journal : BREAST CANCER MANAGEMENT
  • Page Numbers: pp.117-126

Abstract

Breast cancer is a second common form of malignancy and is one of the leading causes of mortality among cancer patients across the world. Locoregional recurrence occurs in 5-20% of patients despite upfront treatment. Local therapy (surgery plus minus re-irradiation) with or without systemic therapy is generally recommended for management. Local control rates vary; months to years, but a significant percentage lives 5 years. Therefore, treatment strategies to increase response rates are significant. Hyperthermia is one of the most potent radiosensitizers and data from meta-analysis and randomized trials support its use with radiotherapy. This study reviews the biologic rationale and clinical evidence about concomitant use of hyperthermia and radiotherapy in locally-recurrent breast cancer patients.