Hyperthermia and radiotherapy combination for locoregional recurrences of breast cancer: a review
BREAST CANCER MANAGEMENT, cilt.6, sa.4, ss.117-126, 2017 (ESCI)
- Yayın Türü: Makale / Derleme
- Cilt numarası: 6 Sayı: 4
- Basım Tarihi: 2017
- Doi Numarası: 10.2217/bmt-2017-0011
- Dergi Adı: BREAST CANCER MANAGEMENT
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI)
- Sayfa Sayıları: ss.117-126
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Breast cancer is a second common form of malignancy and is one of the leading causes of mortality among cancer patients across the world. Locoregional recurrence occurs in 5-20% of patients despite upfront treatment. Local therapy (surgery plus minus re-irradiation) with or without systemic therapy is generally recommended for management. Local control rates vary; months to years, but a significant percentage lives 5 years. Therefore, treatment strategies to increase response rates are significant. Hyperthermia is one of the most potent radiosensitizers and data from meta-analysis and randomized trials support its use with radiotherapy. This study reviews the biologic rationale and clinical evidence about concomitant use of hyperthermia and radiotherapy in locally-recurrent breast cancer patients.