Hyperthermia and radiotherapy combination for locoregional recurrences of breast cancer: a review

Arslan S. A. , Ozdemir N., ŞENDUR M. A. N. , Eren T., Ozturk H. F. , Aral I. P. , ...Daha Fazla

BREAST CANCER MANAGEMENT, cilt.6, sa.4, ss.117-126, 2017 (ESCI İndekslerine Giren Dergi) identifier

  • Yayın Türü: Makale / Derleme
  • Cilt numarası: 6 Konu: 4
  • Basım Tarihi: 2017
  • Doi Numarası: 10.2217/bmt-2017-0011
  • Sayfa Sayıları: ss.117-126


Breast cancer is a second common form of malignancy and is one of the leading causes of mortality among cancer patients across the world. Locoregional recurrence occurs in 5-20% of patients despite upfront treatment. Local therapy (surgery plus minus re-irradiation) with or without systemic therapy is generally recommended for management. Local control rates vary; months to years, but a significant percentage lives 5 years. Therefore, treatment strategies to increase response rates are significant. Hyperthermia is one of the most potent radiosensitizers and data from meta-analysis and randomized trials support its use with radiotherapy. This study reviews the biologic rationale and clinical evidence about concomitant use of hyperthermia and radiotherapy in locally-recurrent breast cancer patients.