ETS-1 proto-oncogene as a key newcomer molecule to predict invasiveness in laryngeal carcinoma

Calli A. O. , Sari A., Cakalagaoglu F., Altinboga A. , Oncel S.

Pathology Research and Practice, vol.207, no.10, pp.628-633, 2011 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 207 Issue: 10
  • Publication Date: 2011
  • Doi Number: 10.1016/j.prp.2011.07.010
  • Title of Journal : Pathology Research and Practice
  • Page Numbers: pp.628-633


ETS-1 protein is one of the key regulators in tumor invasion and progression. We aimed to evaluate the role of ETS-1 in the invasiveness and progression of laryngeal squamous carcinoma, as well as to determine the correlations between clinicopathological characteristics and expression of this molecule.We assessed the levels of ETS-1 in a total of 96 laryngeal specimens of varying degrees of dysplasia, microinvasive squamous carcinoma (8), and invasive squamous carcinoma (60), using normal mucosal epithelium (10) as a positive control. The relationship between ETS-1 expression and clinicopathological parameters of laryngeal carcinoma was also analyzed.We found a significantly higher ETS-1 expression in invasive laryngeal squamous cell carcinomas than in dysplasia (P< 0.001). A correlation between ETS-1 expression scores and grade was detected - T factor, stage, cartilage invasion, lymph node metastasis, as well as depth of invasion in laryngeal tumors.Our study is the first to demonstrate that ETS-1 expression is significantly increased in invasive carcinoma, but it is absent in low-moderate grade laryngeal dysplasia and non-neoplastic laryngeal mucosa. This data suggest that ETS-1 expression may play an important role in tumor invasion, and may function in the initiation of the invasive process in laryngeal squamous cell carcinoma. © 2011 Elsevier GmbH.