© 2020 Neonatal Nurses AssociationLiterature has shown that mothers whose babies are in neonatal intensive care units (NICUs) are at risk of experiencing postpartum depression (PPD). This study explored the relationship between PPD and perceived social support and its impact on maternal adaptation in mothers of new-borns hospitalized in NICUs. Participants were 252 mothers of infants in the NICU. An Individual Form, the Edinburgh PD Scale, the Postpartum Self Evaluation Questionnaire, and the Multidimensional Scale of Perceived Social Support were used for data collection. Mann Whitney U test and Pearson Correlation were used for data analysis. Breastfeeding difficulty, inadequate information on postpartum, psychological disease history, C/S, low birth weight, prematurity, and long hospital stay was found to be predictors of PPD and poor maternal adaptation. As perception of social support and maternal adaptation decreased, PPD symptoms increased. Health providers should detect PPD symptoms of these mothers and have them referred early for counselling.