Hepatoprotective and antioxidant effects of lycopene in acute cholestasis

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Tokac M., Aydin S., Taner G., Ozkardes A. B., Yavuz Taslipinar M., Dogan M., ...More

TURKISH JOURNAL OF MEDICAL SCIENCES, vol.45, no.4, pp.857-864, 2015 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 4
  • Publication Date: 2015
  • Doi Number: 10.3906/sag-1404-57
  • Journal Name: TURKISH JOURNAL OF MEDICAL SCIENCES
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, TR DİZİN (ULAKBİM)
  • Page Numbers: pp.857-864
  • Ankara Yıldırım Beyazıt University Affiliated: Yes

Abstract

Background/aim: Lycopene, which is suggested to be a potent antioxidant, may play a protective role in diseases related to oxidative stress. In order to understand the effects of lycopene in the pathogenesis of cholestasis, we investigated the effects of lycopene on oxidative stress parameters and DNA damage induced by experimental biliary obstruction in the liver tissues and the lymphocytes of Wistar albino rats.