Prognostic significance of the programmed death ligand 1 expression in clear cell renal cell carcinoma and correlation with the tumor microenvironment and hypoxia-inducible factor expression


Dogan H. T. , Kiran M., Bilgin B., Kilicarslan A., Sendur M. A. N. , Yalcin B., ...Daha Fazla

DIAGNOSTIC PATHOLOGY, cilt.13, 2018 (SCI İndekslerine Giren Dergi) identifier identifier identifier

Özet

Background: Clear cell renal cell carcinoma (ccRCC) is the most common renal malignancy. Hypoxia-inducible factors, HIF-1 alpha and HIF-2 alpha, are expressed in the majority of ccRCC. Targeting immune checkpoints with the blockade of PD-1 and its ligand PD-L1 reorganizes T-cell activity in tumor microenvironment and provides important antitumor responses. PD-L1 upregulation has been found to be hypoxia-inducible factor (HIF) dependent. Our aim is to demonstrate the association between PD-L1 and HIF expression and to reveal the role of PD-L1 in prognosis and its association with tumor microenvironment.