Aim: Algorithms for preventing pressure injury should include skin care, activity management, nutrition management, moisture/incontinence management, support surface management, registration, and training. Increased quality of care can be observed through algorithms created through a combination of preventive care phases. Material and Method: The purpose of this prospective, descriptive study was to examine the content validity of the pressure injury prevention algorithm incorporating a combination of the preventive care stages and using a larger sample size of intensive care nurses. Material and Method: All of the intensive care nurses working in Yildirm Beyazit University Ankara Ataturk Training and Research Hospital were invited to participate in the study. A er participants provided written informed consent, demographic variables and opinions on the pressure injury prevention algorithm were collected and participants were asked to comment on and rate the relevance and appropriateness of each of the 101 algorithm decision steps using standard content validation study procedures. Results: Descriptive summary statistics, mean appropriateness scores, and the content validity index (C) were calculated. Of the 96 intensive care nurses invited, 81 consented to participate and completed the study (a response rate of 84). The mean age was 28.35 years (SD 4.55 range 22-41), most participants were female (85.2%), and (38.3%) had > 5 years of intensive care experience. The algorithm's overall mean score was 3.02 (SD: 0.02) all except 1 of the 101 steps had a high C of 0.90 (out of 1.0). Several minor algorithm modifications were made. Discussion: The pressure injury prevention algorithm is valid and appropriate with the addition of the minor modifications. A construct validated pressure injury prevention algorithm may help nurses identify pressure injury and risks and also help them develop appropriate nursing interventions for intensive care patients. It is recommended that large group studies involving the application and evaluation of the pressure injury prevention algorithm be conducted.