Assessment of serum thiol/disulfide homeostasis in multiple myeloma patients by a new method


Guney T., Kanat I. F. , Alkan A. , Alisik M., Akinci S. , SILAY K., ...More

Redox Report, vol.22, no.6, pp.246-251, 2017 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 22 Issue: 6
  • Publication Date: 2017
  • Doi Number: 10.1080/13510002.2016.1180100
  • Title of Journal : Redox Report
  • Page Numbers: pp.246-251
  • Keywords: Disulfide, Multiple myeloma, Oxidative stress, Thiol

Abstract

© 2016 Informa UK Limited, trading as Taylor & Francis Group.Objectives: The etiology of multiple myeloma (MM) is not exactly known. This study investigated the role of thiol/disulfide homeostasis in the etiopathogenesis of MM. Methods: Some 50 patients with MM (aged 39–84 years) and 50 sex-matched healthy volunteer controls (aged 50–91 years) participated in this study. Venous blood samples were collected, and levels of native thiols, total thiols, and disulfide were measured. Results: Native and total thiol levels in the control group were determined to be higher than in the study and patient groups (P<0.001). Disulfide levels were found to be higher in the control group than in the study group and higher in newly diagnosed patients than in outpatients who were undergoing treatment (P=0.002). The ratios of thiol levels were found to be similar in both the study and control groups (P>0.05). Discussion: The results of the study show that although there was a decrease in the levels of disulfide, native thiol, and total thiol, the balance of thiol/disulfide was maintained. This is the first study to research the homeostasis of dynamic thiol/disulfide from the perspective of the new method that was used. We hope that this study will encourage and facilitate further studies in this area.