Relationship between asthma and IL-17 gene polymorphism in a Turkish population
Irish Journal of Medical Science, vol.192, no.1, pp.269-275, 2023 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 192 Issue: 1
- Publication Date: 2023
- Doi Number: 10.1007/s11845-022-02956-5
- Journal Name: Irish Journal of Medical Science
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Biotechnology Research Abstracts, CAB Abstracts
- Page Numbers: pp.269-275
- Keywords: Asthma, IL-17, Polymorphism, rs763780, rs2275913, rs8193036
- Open Archive Collection: AVESIS Open Access Collection
- Ankara Yıldırım Beyazıt University Affiliated: Yes
Abstract
Background: Asthma is a prevalent chronic obstructive disease of the airways. Aims: The aim of our study was to investigate the relationship between asthma and IL-17F gene 74488 T > C, IL-17A gene -197G > A, and IL17A gene -737C > T polymorphisms in Turkish population. Methods: In our study, peripheral blood samples collected from a total of 127 subjects, with 65 in the patient group and 62 in the control group, were analyzed for IL-17F gene 74488 T > C, IL-17A gene -197G > A, and IL17A gene -737C > T polymorphisms using next-generation sequencing. Results: There was no statistically significant relationship between IL-17A gene -197G > A and IL-17A gene -737C > T polymorphisms and the risk of developing asthma. It was found that the risk of developing asthma was 2.9-fold higher in individuals with a C allele in the IL-17F gene 7488 T > C polymorphic site than the individuals with a T allele. It was shown that ATT and GCT haplotype carriers had a greater disease risk compared with the GTT haplotype carriers. Conclusions: In conclusion, IL-17F gene 7488 T > C polymorphism was found to be associated with asthma in the Turkish population. The IL-17 gene should be further investigated as a potential candidate gene in predicting asthma susceptibility and in the treatment of asthma.