Investigation of thiol/disulfide homeostasis in familial mediterranean fever patients

Cakirca G., ÇELİK M. M., Erdal H., NEŞELİOĞLU S., EREL Ö., Basarali M. K., ...More

JOURNAL OF CLINICAL AND ANALYTICAL MEDICINE, vol.9, no.3, pp.231-234, 2018 (ESCI) identifier

  • Publication Type: Article / Article
  • Volume: 9 Issue: 3
  • Publication Date: 2018
  • Doi Number: 10.4328/jcam.5789
  • Journal Indexes: Emerging Sources Citation Index (ESCI), EMBASE
  • Page Numbers: pp.231-234
  • Ankara Yıldırım Beyazıt University Affiliated: Yes


Aim: To determine the thiol/disulfide homeostasis in patients with familial Mediterranean fever (FMF) and its correlation with the levels of inflammatory markers consisting of white blood cell count, erythrocyte sedimentation rate, C-reactive protein and fibrinogen. Material and Method: This study was performed in the internal Medicine department of Mustafa Kemal University Hospital in Turkey. A total of 27 FMF patients in the attack period (AP), 33 FMF patients in the attack-free period (AFP), and 36 healthy controls participated in this study. Thiol/disulfide profile parameters were detected using the novel method of Erel and Neselioglu. Results: Total and native thiol levels of the FMF-AP group were markedly lower than those of healthy controls, while the difference in disulfide level was not statistically significant. Thiol/disulfide levels in the FMF-AFP group were similar to the levels in both the FMF-AP group and healthy controls. Correlation analysis showed a negative correlation between fibrinogen levels and total and native thiol levels, while there was a positive correlation between white blood cell count and disulfide levels in the FMF-AP group. Discussion: The findings suggest that decreased concentrations of total and native thiol in patients with FMF-AP are likely to be an outcome of inflammation-induced oxidative stress.