Research Information System
Türkiye Diyabet ve Obezite Dergisi , vol.8, no.1, pp.13-18, 2024 (Peer-Reviewed Journal)
Aim: The increasing prevalence of diabetes mellitus (DM) brings about a rise in nephropathy, retinopathy, and neuropathy, which are microvascular complications of diabetes. The triglyceride-glucose (TyG) index is a convenient indicator of insulin resistance. It is related to microvascular and macrovascular complications among nonhospitalized patients with diabetes. However, it is unclear if the TyG index poses risks for vascular complications of type 2 DM in hospitalized patients. This study aims to investigate possible relations between this index and the risk of microvascular complications in hospitalized patients with type 2 DM. Material and Methods: The present study included 420 type 2 DM patients who were hospitalized in our clinic between February 2019 and May 2022. The TyG index was measured as fasting triglycerides mg/dL × fasting glucose mg/dL/2. The presence of microalbuminuria (MAU), diabetic neuropathy, chronic kidney disease (CKD), and retinopathy (DR) were evaluated. The data were analzed using IBM SPSS 22.0 statistical software. The level of statistical significance was taken as p<0.05. Results: Among the patients (164 males, 256 females), the median age was 61 years (20-91).. Diabetic nephropathy, retinopathy, and neuropathy rates were 34.0%, 35.4%, and 50.5%, respectively. Patients with diabetic nephropathy had significantly higher TyG index values (9.67±0.84) compared to those without (9.48±0.75, p=0.019). No significant associations were found between the TyG index and retinopathy or neuropathy. Conclusion: High TyG index values were associated with diabetic nephropathy in hospitalized patients with T2DM. The TyG index may be a useful, easy-to-measure marker for early detection and prevention of diabetic nephropathy in clinical settings.