Association between plasma thiol parameters and troponin levels in patients with acute coronary syndrome and prediction of in-hospital ventricular arrhythmia Associação entre parâmetros de tióis plasmáticos e níveis de troponina em pacientes com síndrome coronariana aguda e previsão de arritmia ventricular intra-hospitalar


Erdoğan M., ÖZTÜRK S., Tutar E. Ö. , ARSLAN E. , Çelik M. C. , BAŞTUĞ S. , ...More

Arquivos Brasileiros de Cardiologia, vol.117, no.3, pp.465-473, 2021 (Journal Indexed in SCI Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 117 Issue: 3
  • Publication Date: 2021
  • Doi Number: 10.36660/abc.20190672
  • Title of Journal : Arquivos Brasileiros de Cardiologia
  • Page Numbers: pp.465-473
  • Keywords: Acetyl-CoA-Acyltransferase, Arrhythmias, Cardiacs, Atherosclerosis, Coronary Acute, Syndrome, Coronary Artery Disease, Oxidative Stress

Abstract

© 2021, Arquivos Brasileiros de Cardiologia. All rights reserved.Background: Ventricular arrhythmias (VAs) are the main cause of in-hospital mortality and morbidity in acute coronary syndrome (ACS) patients and its relationship with thiol is not known. Objective: To investigate the relationship between plasma thiol levels and troponin levels in patients with ACS and to estimate in-hospital VA development during hospital stay. Method: The study included 231 consecutive ST-segment elevation ACS (STE-ACS) and non-ST-segment elevation ACS (NSTE-ACS) patients. After application of exclusion criteria, 191 patients were included in the statistical analysis. Patients were classified into two groups: STE-ACS group (n=94) and NSTE-ACS group (n=97). Plasma thiol, disulphide and troponin levels were measured and troponin-to-native thiol ratio (TNTR) was calculated. A two-sided p value of less than 0.05 was considered to be statistically significant. Results: Plasma native thiol, total thiol, disulphide and their ratios were similar between the groups. TNTR was significantly higher in the STE-ACS group compared to the NSTE-ACS group. Troponin and thiol levels correlated negatively and significantly. Native thiol was found to be an independent predictor of VA development in STE-ACS patients and in all ACS patients. TNTR was found to be an independent predictor of VA development in NSTE-ACS patients and in all ACS patients. Conclusion: Plasma thiol levels can be used to identify ACS patients at high risk for in-hospital VA development. Correlation between troponin and thiol levels may suggest that thiols may be an important marker for diagnosis and prognosis of ACS with the help of future studies.