Is IL-33 useful to detect early stage of renal failure?

Caner S., Usluoǧullari C. A., Balkan F., Büyükcam F., Kaya C., Saçikara M., ...More

Renal Failure, vol.36, no.1, pp.78-80, 2014 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 36 Issue: 1
  • Publication Date: 2014
  • Doi Number: 10.3109/0886022x.2013.832313
  • Journal Name: Renal Failure
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.78-80
  • Keywords: Diabetes mellitus, Diagnosis, IL-33, Kidney, Renal failure
  • Ankara Yıldırım Beyazıt University Affiliated: Yes


IL-33 is a proinflammatory cytokine that is a member of IL-1 family. Previously the effect of IL-33 on kidney injury is showed in animal models. In this study, we searched if we can use IL-33 to show the early stage of kidney injury in diabetic patients. Three groups are identified: 26 patients in Group 1: Healthy group, that do not have any chronic diseases and not taking any medication; 42 patients in Group 2: DM (diabetes mellitus) group without any known kidney disease and with normal kidney functions; 32 patients in Group 3: DM+MA (microalbuminuria) group that are assumed to have nephropathy. IL-33 level of DM patient group is greater than healthy group; also IL-33 level of DM+MA patient group is greater than healthy group; but there is not any difference between DM and DM+MA group. The increase in IL-33 levels in diabetic nephropathy is not associated with kidney injury but the increase could be resulting because of diabetes. So IL-33 cannot be used in early recognition of diabetic nephropathy. © 2014 Informa Healthcare USA, Inc.