Childhood Vaccinations in Children With Food or Vaccination-Related Allergic Reactions: A Single-Center Experience

Kutsal Gültekin T. T., İpek Demir K., Şengül Emeksiz Z., Kara Uzun A., Dibek Mısırlıoğlu E.

Clinical Pediatrics, 2025 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Publication Date: 2025
  • Doi Number: 10.1177/00099228251354850
  • Journal Name: Clinical Pediatrics
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, Academic Search Premier, CAB Abstracts, CINAHL, EBSCO Education Source, EMBASE, Public Affairs Index, Veterinary Science Database
  • Keywords: alpha-lactalbumin, childhood vaccination programs, children, food allergy, immunization, measles vaccine, MMR vaccine, vaccination-related allergic reactions, vaccine, vaccine anaphylaxis
  • Ankara Yıldırım Beyazıt University Affiliated: No

Abstract

Background: Children with allergic reactions are mostly referred to tertiary centers for vaccination, but confirmed vaccination-triggered allergic reactions are uncommon. In this study, childhood vaccination-triggered allergic reactions in children with food and vaccination-related allergies are evaluated. Methodology: Retrospective analysis of 923 doses of vaccine administered in our clinic due to food or vaccine-triggered allergic reactions were conducted. Results: 868 vaccines were measles-mumps-rubella (MMR) vaccine, 20 were measles vaccine containing alpha-lactalbumin and 35 were other childhood vaccines. A total of 576 of MMR vaccines contained alpha-lactalbumin and 292 did not. Vaccinations were administered without any reactions in 98.9% of patients with previous food allergies. One of the reactions was anaphylaxis. About 55 patients were referred because of previous vaccination-related allergic reactions, and 94.5% of them were vaccinated without any reactions. Mild reactions were encountered in 3 (5.5%) patients. No anaphylaxis was observed. Conclusion: Patients with a history of food or vaccination allergies have a low rate of allergic reactions in childhood vaccinations.