Predictive value of ischaemia-modified albumin in spermatogenesis in an experimental testicular torsion model


Kutluhan M. A. , Urkmez A., Sahin A., Topaktas R., Gumrukcu G., Verit A.

Andrologia, cilt.52, 2020 (SCI Expanded İndekslerine Giren Dergi) identifier identifier

  • Cilt numarası: 52 Konu: 2
  • Basım Tarihi: 2020
  • Doi Numarası: 10.1111/and.13471
  • Dergi Adı: Andrologia

Özet

© 2019 Blackwell Verlag GmbHOur aim was to measure the ability of ischaemia-modified albumin (IMA) to predict testicular histopathological damage in the testes of rats with short- and long-term ischaemia using experimental testicular torsion and subsequent reperfusion via detorsion.21 Wistar Albino rats were randomized into three groups. The sham group was subjected to a mid-scrotal incision only. The 4- and 8-hr T/D (Torsion/Detorsion) groups were subjected to left testicular torsion by twisting the testes by 720 degrees counterclockwise. 2 cc venous blood samples were taken from the sham group after the mid-scrotal incision, and from the 4- and 8-hr T/D groups after 4 and 8 hr respectively. After that, the 4- and 8-hr T/D groups were subjected to detorsion. Two days later, orchiectomy was performed. Ischaemia-modified albumin levels were significantly different among the groups at 48 hr prior to orchiectomy (reperfusion; p =.003). Based on the results of the paired comparisons, it was found that IMA levels of the sham group were significantly higher than those of the 4- and 8-hr T/D groups (p =.002 and.009 respectively). Our study has showed that IMA may be used to predict ischaemia/reperfusion injury, which is another complication that may occur following detorsion in testicular torsion.