Thiol Disulfide Homeostasis in Pseudoexfoliation Syndrome


Tetikoglu M., Aktas S., Sagdik H. M. , ÖZCURA F., Ucar F., Kocak H., ...Daha Fazla

CURRENT EYE RESEARCH, cilt.42, ss.876-879, 2017 (SCI İndekslerine Giren Dergi) identifier identifier identifier

  • Cilt numarası: 42 Konu: 6
  • Basım Tarihi: 2017
  • Doi Numarası: 10.1080/02713683.2016.1256412
  • Dergi Adı: CURRENT EYE RESEARCH
  • Sayfa Sayıları: ss.876-879

Özet

Purpose: To determine the serum thiol disulfide homeostasis in patients with pseudoexfoliation (PEX) syndrome.Method: Thirty-five patients with PEX syndrome and forty healthy subjects were included in this observational case-control study. Serum native thiol, total thiol, disulfide, and native thiol/disulfide ratio were determined using a novel and automated assay.Results: The mean serum total thiol and native thiol levels were significantly lower in patients with PEX syndrome compared to healthy controls (p = 0.001). The mean serum disulfide level was significantly higher in patients with PEX syndrome compared to healthy controls (p = 0.023). The serum native thiol/disulfide ratio was lower in patients with PEX syndrome compared to healthy subjects (16 10.1 vs 22.3 +/- 11.5, respectively, p = 0.014).Conclusion: Our findings provide evidence that the dynamic native thiol/disulfide ratio is lower in PEX syndrome, which shows a reduction in the natural cell reductive capacity reservoir.