Levetiracetam treatment in an experimental model of sciatic nerve injury: A randomized controlled trial

Apaydin A. S., Sahin C., ÇAYLI S., BAL E., Bal C., Gökcem Yildiz F., ...More

Neurological Research, vol.45, no.1, pp.86-96, 2023 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 45 Issue: 1
  • Publication Date: 2023
  • Doi Number: 10.1080/01616412.2022.2143617
  • Journal Name: Neurological Research
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, MEDLINE
  • Page Numbers: pp.86-96
  • Keywords: antioxidants, gait analysis, levetiracetam, Rat, sciatic neuropathy
  • Ankara Yıldırım Beyazıt University Affiliated: Yes


© 2022 Informa UK Limited, trading as Taylor & Francis Group.Aim: This study examined whether levetiracetam contributes to improvements in the axon-nerve damage in an experimental rat model. Materials and Methods: Forty-eight Wistar albino adult male rats weighing 250–300 gr were randomized into six groups having or not having sciatic nerve damages and receiving different (none, 300 and 600 mg/kg) levetiracetam doses, and control (non-levetiracetam). Functional gait analysis and tissue sample analysis with the aid of light microscopy and hematoxylin-eosin dye were evaluated between the groups. Additionally, scanning electron microscopy (SEM) was used for the detailed examination of sciatic nerves. S-100 (Schwann cell marker) immunoreactivities in sciatic nerve was detected by immunohistochemistry. Results: Sciatic functional index of the injured rats receiving 300 mg/kg levetiracetam was −65.59 ± 29.48 and −47.13 ± 21.36 in the 2nd and 6th weeks, respectively (p < 0.001). Also, IMA and TOS levels were significantly higher in the control group compared to those receiving levetiracetam (p = 0.001 and p < 0.001, respectively). The most significant nerve regeneration was in the group injured and treated with LEV 600 mg/kg (p < 0.05). Conclusion: There was a significant improvement in the sciatic functional index, histopathological findings, and parameters showing tissue oxidant status in rats with sciatic nerve injury receiving levetiracetam treatment. Further investigations should be performed to evaluate the contribution of levetiracetam as a treatment modality in sciatic nerve injuries.