IS DYNAMIC THIOL/DISULFIDE HOMEOSTASIS ASSOCIATED WITH THE PROGNOSIS OF GERIATRIC PATIENTS WITH SEPSIS IN THE INTENSIVE CARE UNIT?
Turk Geriatri Dergisi, cilt.25, sa.4, ss.495-503, 2022 (SCI-Expanded, SSCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 4
- Basım Tarihi: 2022
- Doi Numarası: 10.31086/tjgeri.2022.307
- Dergi Adı: Turk Geriatri Dergisi
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Social Sciences Citation Index (SSCI), Scopus, Academic Search Premier, EMBASE, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.495-503
- Anahtar Kelimeler: Aged, Intensive Care Units, Sepsis, Sulfhydryl Compounds
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Introduction: Sepsis is an important cause of mortality, especially in geriatric patients hospitalized in the intensive care unit. Our study aims to evaluate the effectiveness of thiol / disulfide homeostasis in determining the mortality of geriatric patients admitted to intensive care unit due to sepsis. Materials and Method: Our study was designed prospectively in patients aged 65 years and older with geriatric sepsis hospitalized in the intensive care unit between January 2018 and March 2019. Thiol-disulfide homeostasis was measured at the time of hospitalization. Demographic and clinical characteristics and thiol – disulfide homeostasis levels were compared in patients with mortality and surviving. Results: 252 geriatric patients with sepsis were included in the study. A total of 148 (58.7%) of the patients died, 104 (41.3%) were discharged alive. In the group with mortality, native-thiol, total-thiol and disulfide levels were found to be significantly lower compared to the surviving group (p <0.05). In geriatric patients with sepsis; levels of native-thiol less than 209 μmol / L, total-thiol lesss than 248 μmol / L and disulfide being less than 20.4 μmol / L was found as the cut-off value for mortality (p=0.0001). Conclusion: This study showed that low native-thiol, total-thiol and disulfide levels may be associated with mortality in patients with geriatric sepsis hospitalized for the first time in the intensive care unit.