Research Information System
Clinical and Investigative Medicine, vol.33, no.5, 2010 (SCI-Expanded, Scopus)
Purpose: We evaluated and compared the oxidant and antioxidant status of hyperbilirubinemic infants before and after the two forms of phototherapy: conventional and LED phototherapy, in order to identify the optimal treatment method. Method: Thirty newborns exposed to conventional (Group I) phototherapy and 30 infants exposed to LED phototherapy (Group II) were studied. The serum total antioxidant capacity (TAC) and the total oxidant status (TOS) were assessed by EREL's method. Results: There were no statistically significant differences in TAC or TOS levels between Group I and Group II prior to phototherapy, and no statistically significant difference in TAC levels between the two groups after phototherapy; however, TOS levels were significantly lower in Group II compared to Group I after phototherapy. Oxidative stress index (OSI) increased after conventional phototherapy (p<0.05) Conclusion: The increase in TOS following conventional phototherapy was not not observed following LED phototherapy. This difference should be considered when using phototherapy. Most newborns become clinically jaundiced during the first week of life. Bilirubin is normally cleared from the body by hepatic conjugation with glucuronic acid and eliminated in bile in the form of bilirubin glucuronides, but since the neonatal liver can not adequately clear bilirubin, bilirubin accumulation is observed. High levels of bilirubin are toxic to the central nervous system, so rapid intervention is necessary. © 2010 CIM.