Success of Combination Therapy with Isavuconazole in a Pediatric Patient with Breakthrough Invasive Aspergillosis
Journal of Pediatric Infectious Diseases, vol.19, no.4, pp.242-246, 2024 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 19 Issue: 4
- Publication Date: 2024
- Doi Number: 10.1055/s-0044-1788048
- Journal Name: Journal of Pediatric Infectious Diseases
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.242-246
- Keywords: aspergillosis, isavuconazole, pediatric, salvage treatment
- Open Archive Collection: AVESIS Open Access Collection
- Ankara Yıldırım Beyazıt University Affiliated: Yes
Abstract
The increasing incidence of invasive fungal infections, coupled with the growing population of immunocompromised patients, has led to an increased need for antifungal agents. The newest azole, isavuconazole, plays an important role in the treatment of invasive aspergillosis in adults due to its broad spectrum, tolerability, and no need for therapeutic drug monitoring. This agent, which has not yet been approved for use in children, has significant problems with drug supply in Türkiye. We present the treatment response to isavuconazole combination therapy used in salvage treatment in a patient with breakthrough invasive aspergillosis, who had treatment failure with different antifungal combination treatment options and surgical resection.