Role of circulating nesfatin-1 in the underweight children with poor appetite

Kaba S., Karaman K., Kömüroǧlu U., Bala K., Demir N., Kocaman S., ...More

European Review for Medical and Pharmacological Sciences, vol.19, no.24, pp.4703-4706, 2015 (SCI-Expanded) identifier identifier

  • Publication Type: Article / Article
  • Volume: 19 Issue: 24
  • Publication Date: 2015
  • Journal Name: European Review for Medical and Pharmacological Sciences
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.4703-4706
  • Keywords: Childhood, Loss of appetite, Nesfatin-1
  • Ankara Yıldırım Beyazıt University Affiliated: Yes


OBJECTIVE: To investigate serum concentration of nesfatin-1 in underweight children who have poor appetite, and its association with anthropometric markers of malnutrition. PATIENTS AND METHODS: We recruited 50 underweight children and adolescents (aged 2-18 years) who presented with loss of appetite. Thirty age- and sex-matched controls were also included in the study. Fasting serum nesfatin-1 concentrations were measured by using Enzyme-Linked Immunosorbent Assay (ELISA) technique. RESULTS: Mean nesfatin-1 level was significantly higher in underweight children when compared to controls (p < 0.001). There was no correlation between serum nesfatin-1 levels and anthropometrics markers. CONCLUSIONS: Our results suggest that nesfatin-1 might have an important role in regulation of food intake and pathogenesis of loss of appetite in children.