Protective effects of melatonin and selenium against apoptosis of olfactory sensory neurons: A rat model study


Koc S., ÇAYLI S. , Aksakal C., OCAKLI S., Soyalic H., SOMUK B. T. , ...More

AMERICAN JOURNAL OF RHINOLOGY & ALLERGY, vol.30, no.3, 2016 (Journal Indexed in SCI) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 30 Issue: 3
  • Publication Date: 2016
  • Doi Number: 10.2500/ajra.2016.30.4313
  • Title of Journal : AMERICAN JOURNAL OF RHINOLOGY & ALLERGY

Abstract

Background: Selenium plays a role in the prevention of oxidative damage and has been linked to regulatory functions in cell growth, apoptosis, cell survival, and cytotoxicity. Melatonin has an antioxidant effect, which protects against a number of free radical species. Given its antioxidant properties, melatonin has been widely known to inhibit neuronal apoptosis. We examined the cytoprotective effects of melatonin and selenium in rat olfactory sensory neurons after rhinosinusitis by immunohistochemical evaluation of olfactory bulb mucosa.