Comparison of Ischemia-Modified Albumin Levels in Infertile Men With Mild, Moderate, and Severe Oligozoospermia
Andrologia, cilt.2026, sa.1, 2026 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 2026 Sayı: 1
- Basım Tarihi: 2026
- Doi Numarası: 10.1155/and/3829950
- Dergi Adı: Andrologia
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, EMBASE, Gender Studies Database
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: The objective of this study is to determine whether IMA (Ischemic Modified Albumin), a new oxidative stress (OS) marker, can be used to predict the degree of oligozoospermia in infertile men. Materials and Methods: Oligozoospermic male patients (n = 113) who remained infertile despite regular, unprotected sexual intercourse for more than 12 months were included in the study. Those with sperm counts of 10–16 × 106/ml were classified as having mild oligozoospermia (group 1, n = 32), those with counts of 5–9.9 × 106/ml were classified as moderate oligozoospermia (group 2, n = 42), and those with <5 × 106/ml were classified as severe oligozoospermia (group 3, n = 39). Additionally, normospermic (>16 × 106/ml) fertile men with at least one child (group 4, n = 47) were included as the control group. Results: When IMA levels were compared between the infertile group and the control group, they were found to be statistically significantly higher in the infertile group (p = 0.002). When the oligozoospermia groups were compared with the control group, the difference between the groups was found to be statistically significant (p = 0.017). The IMA level of the severe oligozoospermia group was found to be significantly higher than the IMA levels of the control, moderate, and mild oligozoospermia groups (p < 0.05); however, the IMA levels of the moderate and mild oligozoospermia groups did not show a statistically significant difference from the control group (p > 0.05). The IMA levels of the general study group were found to show a statistically significant difference according to sperm motility (p = 0.001). In addition, the IMA levels of patients with varicocele were found to be significantly higher (p = 0.035). IMA showed a positive correlation with estradiol (p = 0.004) and triiodothyronine (p = 0.022) levels. Conclusion: This study suggests that serum IMA levels were found to be significantly associated with severe oligozoospermia, suggesting a potential relationship between systemic oxidative burden and disease severity.