Acute hepatitis C virus (HCV) infection has an asymptomatic course in most patients. There is no sufficient data regarding its epidemiological features. Recent advances in the treatment of chronic HCV infection have led also to discuss on acute HCV treatment. The possibility of spontaneous clearance, absence of reduction in response rates with delayed treatment, and being curable easily with new directly acting agents brought interferon free treatment to the agenda. Current guidelines made some changes in the recommendations for optimal duration of treatment and treatment options for acute HCV infection. We aimed to review the treatment of acute HCV infection in the light of current data.