The Levels of the Circulating Cellular Adhesion Molecules ICAM-1, VCAM-1 and Endothelin-1 and the Flow-mediated Vasodilatation Values in Patients with Type 1 Diabetes Mellitus with Early-stage Diabetic Retinopathy

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Ugurlu N., Gerceker S., Yulek F., Ugurlu B., Sari C., Baran P., ...More

INTERNAL MEDICINE, vol.52, no.19, pp.2173-2178, 2013 (SCI-Expanded) identifier identifier identifier

  • Publication Type: Article / Article
  • Volume: 52 Issue: 19
  • Publication Date: 2013
  • Doi Number: 10.2169/internalmedicine.52.8572
  • Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
  • Page Numbers: pp.2173-2178
  • Ankara Yıldırım Beyazıt University Affiliated: Yes


Objective Endothelial dysfunction plays an important role in the development of diabetic retinopathy. The aim of this study was to evaluate endothelial dysfunction using different approaches in patients with type 1 diabete mellitus with early stages of diabetic retinopathy. For this purpose, we investigated the serum levels of cellular adhesion molecules, including intercellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and endothelin-1 (ET-1), which have emerged as specific markers of endothelial dysfunction, and measured the flow-mediated dilatation (FMD), a noninvasive technique used to evaluate endothelial dysfunction.