The Levels of the Circulating Cellular Adhesion Molecules ICAM-1, VCAM-1 and Endothelin-1 and the Flow-mediated Vasodilatation Values in Patients with Type 1 Diabetes Mellitus with Early-stage Diabetic Retinopathy

Ugurlu, Nagihan; Gerceker, Sidika; Yulek, FATMA; Ugurlu, Burcak; Sari, Cenk; Baran, Pervin; Cagil, Nurullah

doi:10.2169/internalmedicine.52.8572

The Levels of the Circulating Cellular Adhesion Molecules ICAM-1, VCAM-1 and Endothelin-1 and the Flow-mediated Vasodilatation Values in Patients with Type 1 Diabetes Mellitus with Early-stage Diabetic Retinopathy

Atıf İçin Kopyala

Ugurlu N., Gerceker S., Yulek F. , Ugurlu B., Sari C., Baran P., ...Daha Fazla

INTERNAL MEDICINE, cilt.52, sa.19, ss.2173-2178, 2013 (SCI İndekslerine Giren Dergi)

Cilt numarası: 52 Konu: 19
Basım Tarihi: 2013
Doi Numarası: 10.2169/internalmedicine.52.8572
Dergi Adı: INTERNAL MEDICINE
Sayfa Sayıları: ss.2173-2178

Özet

Objective Endothelial dysfunction plays an important role in the development of diabetic retinopathy. The aim of this study was to evaluate endothelial dysfunction using different approaches in patients with type 1 diabete mellitus with early stages of diabetic retinopathy. For this purpose, we investigated the serum levels of cellular adhesion molecules, including intercellular adhesion molecule (ICAM-1), vascular cell adhesion molecule (VCAM-1) and endothelin-1 (ET-1), which have emerged as specific markers of endothelial dysfunction, and measured the flow-mediated dilatation (FMD), a noninvasive technique used to evaluate endothelial dysfunction.