© 2020 Wiley Periodicals, Inc.Objective: The aim of this study was to determine the effects of preparation vs nonpreparation of tooth surfaces and the types of porcelain laminate veneers (PLVs) on color changes after 300 hours of artificially accelerated aging (AAA). Materials and methods: Forty extracted maxillary central incisors were used. The teeth were divided into four groups (n = 10) to evaluate preparation methods and porcelain types: Group A: tooth preparation with IPS e.max computer-assisted design (CAD), group B: tooth preparation with IPS e.max press, group C: nonpreparation with IPS e.max CAD, and group D: nonpreparation with IPS e.max press. Veneers were fabricated and cemented using a dual-polimerized cement. Initial color measurement was performed and repeated after AAA. Color changes were calculated with the CIEDE 2000 (ΔE00) formula. Color differences were analyzed with two-way ANOVA (P <.05). Results: The two-way ANOVA test showed no significant difference among the groups (P >.05). The highest color change value was observed in group C, followed by groups B, A, and D. Conclusion: Preparation of veneers caused more color changes in PLVs than nonpreparation. However, IPS e.max CAD systems for fabrication of nonprepared PLVs increased the color change of the PLVs measured after AAA. Clinical Significance: The results provide information on the effect of the amount of preparation and the type of porcelain on color change in porcelain laminate veneers. In terms of esthetic dentistry, IPS e.max press and non-prep treatment should be used in the anterior region, where esthetics are important.