Glabridin alleviates ischemia/reperfusion-induced functional failure of smooth muscle of rat ileum by upregulating the camp Glabridin alivia la falla funcional inducida por isquemia/reperfusión del músculo liso de ileum murino regulando el incremento de camp
Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas, cilt.19, sa.6, ss.555-568, 2020 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 19 Sayı: 6
- Basım Tarihi: 2020
- Doi Numarası: 10.37360/blacpma.20.19.5.39
- Dergi Adı: Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus, BIOSIS, CAB Abstracts, EMBASE, Veterinary Science Database
- Sayfa Sayıları: ss.555-568
- Anahtar Kelimeler: CAMP, CGMP, Glabridin, Ileum contractility, Intestinal ischemia/reperfusion, Oxidative injury
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Despite the development of modern medicine, alternative medicine, which has not lost its timeliness, remains attractive for t he treatment of various diseases. Glabridin, a major flavonoid of Glycyrrhiza glabra, is known for its antioxidant and anti-inflammatory activity. The aim of this study was: 1) to determine the possible protective role of glabridin against ischemia/reperfusion ( I/R) injury of the intestine; 2) to evaluate the in vitro contractile responses of ileum smooth muscles to acetylcholine after an intestinal I/R; and 3) to explain the underlying molecular mechanism of its effect. Rats were assigned to groups of six rats each; 1) I/R, 2) gla10, 3) gla20, 4) gla40, 5) N5-[imino(nitroamino)methyl]-L-ornithine, methyl ester monohydrochloride (L-NAME)+gla40, and 6) Sham group. The healing effect of glabridin was abolished by L-NAME. Glabridin did not cause contractility of the smooth muscles to acetylcholine-induced contractile responses in intestinal I/R. Yet, it increased to spontaneous basal activity.