The role of thiol-disulfide homeostasis in gouty arthropathy Tiyol-disülfit homeostazının gut artropatisindeki rolü
Journal of Turkish Society For Rheumatology, cilt.17, sa.1, ss.15-19, 2025 (Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 17 Sayı: 1
- Basım Tarihi: 2025
- Doi Numarası: 10.4274/raed.galenos.2025.61687
- Dergi Adı: Journal of Turkish Society For Rheumatology
- Derginin Tarandığı İndeksler: Scopus, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.15-19
- Anahtar Kelimeler: disulfide, Gout, oxidative stress, thiol, thiol-disulfide homeostasis
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: Gout, the most common form of crystal-induced arthritis, is characterized by the accumulation of monosodium urate crystals within the joints. This study aimed to examine thiol-disulfide homeostasis in patients with gouty arthropathy during periods of acute attack and remission. Methods: A novel spectrophotometric technique was employed to assess native thiol (NT) and disulfide levels in gout patients and age-and sex-matched healthy controls. A total of 90 patients and 86 healthy individuals were evaluated using clinical and laboratory data extracted from their medical records. Results: The findings demonstrated that NT and total thiol (TT) levels in patients were significantly lower than in controls (p<0.001 for both). No significant differences in NT and TT levels were observed between acute attacks and remission periods (p>0.05). Conclusion: Alterations in thiol-disulfide homeostasis were evident in gout patients; however, these changes did not vary between periods of acute attack and remission.