© 2021 University of Ankara. All rights reserved.Objective: The concept of microbiota, which is defined as microorganisms living in our bodies, is quite popular today. It is defined as a new organ with the researches carried out in recent years. The purpose of writing this review is to evaluate the effect of microbiota, which has very important functions and effects for the human body, on chronic diseases. Result and Discussion: Microbiota, which has different characteristics specific to each individual, has effects on the development of chronic diseases. Especially hypertension, diabetes, cancer, inflammatory bowel disease, Alzheimer's, Parkinson can be given as examples of these diseases. For this reason, it is very important to maintain and develop healthy Microbiota activity. It is thought that planning trainings, directing and supporting correct health behaviors within the framework of individuals defined as a risky group and those with chronic diseases will contribute to this process.