Evaluation of endocrine & metabolic dysfunctions after hematopoietic stem cell transplantation in children: A study from Turkey
Journal of Pediatric Endocrinology and Metabolism, vol.30, no.6, pp.683-691, 2017 (SCI-Expanded, Scopus)
- Publication Type: Article / Article
- Volume: 30 Issue: 6
- Publication Date: 2017
- Doi Number: 10.1515/jpem-2016-0306
- Journal Name: Journal of Pediatric Endocrinology and Metabolism
- Journal Indexes: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Page Numbers: pp.683-691
- Keywords: Children, Endocrine, Stem cell transplantation
- Ankara Yıldırım Beyazıt University Affiliated: No
Abstract
Background: Endocrine organs are highly susceptible to effects of high-dose chemotherapy. The objective of the study was to evaluate endocrine and metabolic complications after hematopoietic stem cell transplantation (HSCT) in children. Methods: The patients who underwent HSCT in our center from April 2010 to October 2014 with at least 1 year followup were analyzed retrospectively. Results: One-hundred children (M/F:59/41; mean age 8.9 7plusmn;4.8 years, mean follow-up time 3.4 ±1.2 years) were included in the study. Female hypogonadism was the most common endocrine dysfunction (35.7%), followed by growth impairment (29.4%), malnutrition (27.4%), dyslipidemia (26%), low bone mineral density (BMD) (25%), hypothyroidism (13%) and insulin resistance (12%). Patients who underwent HSCT ?10 years of age were significantly at risk for hypogonadism, metabolic syndrome, growth impairment and malnutrition (p <0.05). Conclusions: Endocrine or metabolic dysfunctions are more prevalent in children who are older than 10 years of age at HSCT. Children who underwent HSCT should be followed-up by a multidisciplinary team during puberty and adolescence.