Evaluation of Thiol-disulfide Homeostasis and Ischemia-modified Albumin Levels in Patients Presenting to the Emergency Department in the Postictal Period Postiktal Dönemde Acil Servise Başvuran Hastalarda Tiyol-disülfid Homeostazisinin ve İskemi-modifiye Albümin Düzeyinin Değerlendirilmesi
Turk Noroloji Dergisi, cilt.29, sa.2, ss.118-125, 2023 (ESCI, Scopus, TRDizin)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 29 Sayı: 2
- Basım Tarihi: 2023
- Doi Numarası: 10.4274/tnd.2023.77012
- Dergi Adı: Turk Noroloji Dergisi
- Derginin Tarandığı İndeksler: Emerging Sources Citation Index (ESCI), Scopus, Academic Search Premier, CINAHL, EMBASE, Directory of Open Access Journals, TR DİZİN (ULAKBİM)
- Sayfa Sayıları: ss.118-125
- Anahtar Kelimeler: Epilepsy, ischemia-modified albumin, oxidative stress, thiol-disulfide homeostasis
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: Epileptic seizures are thought to increase oxidative stress. This study aims to show how thiol-disulfide homeostasis (TDH) and ischemia-modified albumin (IMA) values, which are oxidative stress parameters, affect patients with epileptic seizures. Materials and Methods: This study is a prospective, clinical trial, case-controlled trial. A total of 51 patients who were admitted to the emergency department with epileptic seizures and 51 healthy volunteers were enrolled in this study. Oxidative stress and lactate values were measured from blood samples that were drawn intravenously from the patient group, and these biomarkers were compared with the healthy control group. Results: Statistically significant differences were found between patients in the epilepsy and control groups for all IMA values (P < 0.001) and for all TDH values except disulfide (P < 0.001). Native thiol and total thiol levels were found statistically significantly lower in patients with status epilepticus than in patients with only epileptic seizures (P < 0.001). Conclusion: It has been seen that epileptic attack increases oxidative stress. TDH and IMA levels are affected statistically significantly after epileptic seizure. Especially the decrease in native thiol and total thiol levels is noticeable in patients with status epilepticus.