Reported below are the results from a study aimed at mitigating the deleterious alkali-silica reaction by using perlite powder as an admixture. The expansion of mortar bars containing various amounts of silica fume (SF), expanded perlite, and natural perlite was studied. Two kinds of reactive aggregates were used in the study: highly reactive river aggregate containing opal and marginally reactive monzo-diorite aggregate. Expanded perlite and silica fume were tested with both aggregate, separately; on the other hand, natural perlite was tested only with monzo-diorite aggregate. The bars were cast in accordance with ASTM C1260, accelerated mortar bar method, and were stored in NaOH solution for 30 days. Length changes were measured and reported. The results showed that both expanded and natural perlite powder (NPP) have potential to suppress the deleterious alkali-silica expansion. © 2004 Elsevier Ltd. All rights reserved.