Total oxidant/antioxidant status in jaundiced newborns before and after phototherapy Estado oxidante/antioxidante total em recém-nascidos ictéricos antes e depois da fototerapia
Jornal de Pediatria, cilt.83, sa.4, ss.319-322, 2007 (Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 83 Sayı: 4
- Basım Tarihi: 2007
- Doi Numarası: 10.2223/jped.1645
- Dergi Adı: Jornal de Pediatria
- Derginin Tarandığı İndeksler: Scopus
- Sayfa Sayıları: ss.319-322
- Anahtar Kelimeler: Antioxidants, Infant, Malondialdehyde, Oxidative stress, Phototherapy
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: To assess the effect of phototherapy on serum oxidant and antioxidant status in hyperbilirubinemic full-term newborns. Method: Thirty-four full-term infants from 3 to 10 days of age exposed to phototherapy were studied. The serum antioxidant status was assessed by measuring the total antioxidant capacity (TAC) and individual antioxidant components: vitamin C, uric acid, albumin, thiol contents and total bilirubin. The oxidant status was assessed by determining the total oxidant status (TOS), oxidative stress index (OSI) and individual oxidant components: malondialdehyde (MDA), and lipid hydroperoxide levels. Results: Vitamin C, uric acid, total bilirubin and MDA concentration were significantly lower, whereas serum TOS, lipid hydroperoxide and OSI levels were significantly higher after phototherapy (p < 0.05). There were significant positive correlations between serum total bilirubin and MDA (r = 0.434, p = 0.001). Conclusions: Although the MDA level was reduced after phototherapy, phototherapy has a negative impact on numerous parts of the oxidant/antioxidant defense system in jaundiced full-term newborns, exposing them to potential oxidative stress. Copyright © 2007 by Sociedade Brasileira de Pediatria.