Dynamic thiol-disulfide homeostasis in hyperemesis gravidarum
Journal of Perinatology, cilt.35, sa.10, ss.788-792, 2015 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 35 Sayı: 10
- Basım Tarihi: 2015
- Doi Numarası: 10.1038/jp.2015.81
- Dergi Adı: Journal of Perinatology
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.788-792
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Objective: To determine serum thiol-disulfide homeostasis in hyperemesis gravidarum. Study Design: Twenty-six pregnant women with hyperemesis gravidarum and 37 healthy pregnant women were included in the study. Native thiol, disulfide and total thiol concentrations were measured with a novel automated method. Results: Serum disulfide levels were 15.68±4.41 μmol l-1 in the hyperemesis gravidarum group and 13.49±2.81 μmol l-1 in the healthy group (P=0.031). Native thiol levels were 213.86±26.29 μmol l-1 in the hyperemesis gravidarum group and 232.18±19.21 μmol l-1 in healthy group (P=0.004), and total thiol levels were 245.23±28.58 μmol l-1 in the hyperemesis gravidarum group and 259.17±19.94 μmol l-1 in the healthy group (P=0.038). Conclusion: Native and total thiol were deficient in the hyperemesis gravidarum group and this deficiency was correlated with the severity of the disease. The thiol-disulfide balance has shifted to the oxidative side. This metabolic disturbance may have a role in the pathogenesis of hyperemesis gravidarum.