The Significance of Hematological Parameters in Predicting Disease Activity in Chronic Spontaneous Urticaria and Their Changes with Omalizumab: A Retrospective Cohort Study Kronik Spontan Ürtikerde Hastalık Aktivitesini Öngörmede Hematolojik Parametrelerin Önemi ve Omalizumab ile Değişimleri: Retrospektif Bir Kohort Çalışması
Turkiye Klinikleri Dermatoloji, vol.34, no.2, pp.59-67, 2024 (Scopus)
- Publication Type: Article / Article
- Volume: 34 Issue: 2
- Publication Date: 2024
- Doi Number: 10.5336/dermato.2023-100276
- Journal Name: Turkiye Klinikleri Dermatoloji
- Journal Indexes: Scopus, Academic Search Premier, CAB Abstracts
- Page Numbers: pp.59-67
- Keywords: C-reactive protein, CBC-derived biomarkers, Chronic spontaneous urticaria, omalizumab, total immunoglobulin E
- Ankara Yıldırım Beyazıt University Affiliated: Yes
Abstract
Objective: To investigate the change of neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), neutrophil-to-monocyte ratio (NMR), mean platelet volume (MPV), the red blood cell distribution width (RDW), C-reactive protein (CRP), and total immunoglobulin E (IgE) with omalizumab treatment in patients with chronic spontaneous urticaria (CSU). Additionally, to evaluate the relationship between complete blood cell count (CBC)-derived biomarkers and urticaria activity score (UAS7), as well as their relationship with CRP and total IgE, known indicators of disease activity in CSU. Material and Methods: CBC, CRP, total IgE and UAS7 values of 101 patients before and at the 12th week of treatment were analyzed retrospectively. Results: Before the omalizumab treatment, a significant difference was found between the mild+moderate and severe urticaria groups for the NLR (p=0.023) and NMR (p=0.019). At the 12th week of treatment; a significant increase was observed in MPV (p=0.010), LMR (p=0.031), and total IgE (p<0.001) while NLR (p<0.001), PLR (p=0.013), NMR (p<0.001) and CRP (p<0.001) significantly decreased. There was no significant correlation between CBC-derived biomarkers and UAS7 before and after the treatment. Of the CBC-derived biomarkers, only RDW and MPV showed a weak correlation with CRP. Besides, solely NMR had a weak negative correlation with total IgE just for post-treatment. Conclusion: NLR and NMR may reflect the severity of CSU. The inflammatory biomarkers showed a significant change during omalizumab treatment. Omalizumab inhibits inflammation as well as having anti-IgE effect. The lack of correlation between the biomarkers and UAS7 may be attributed to the involvement of different complex inflammatory pathways in the pathogenesis of urticaria.