© 2021 Japan Society of Obstetrics and Gynecology.Aim: This study investigated the association between quality of life and complementary and alternative medicine (CAM) use in pregnant women with hyperemesis gravidarum in Turkey. Methods: This cross-sectional descriptive study was conducted between October 2017 and July 2018 in Turkey. The sample consisted of 240 pregnant women with hyperemesis gravidarum. Data were collected using a Demographic Information Form, the Index of Nausea, Vomiting, Retching, and the 36-item Short-Form Health Survey. Results: The majority (84.2%) of participants stated that they used CAM, mostly “biologically based therapies” (97.5%). They were most satisfied with the “mental and physical treatments” (3.71 ± 1.74). Participants who did not use CAM had a higher quality of life “emotional role” than those who used CAM (p = 0.038). However, there were no statistically significant differences in the other quality of life subscale scores between the two groups. Conclusion: There is limited evidence for the association between quality of life and CAM use in pregnant women with hyperemesis gravidarum in Turkey. Therefore, more evidence-based research is warranted to evaluate the association between CAM use and quality of life in pregnant women with hyperemesis gravidarum.