THE EFFECT OF 3,5-BIS(2-FLUOROBENZYLIDENE)-4-PIPERIDONE (EF24) MOLECULE ON THE METASTASIS MECHANISM IN PROSTATE CANCER CELLS
UBAK Yayınevi, 2025
- Yayın Türü: Kitap / Araştırma Kitabı
- Basım Tarihi: 2025
- Yayınevi: UBAK Yayınevi
- Açık Arşiv Koleksiyonu: AVESİS Açık Erişim Koleksiyonu
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Prostate cancer is one of the most common types of cancer in men. Current
therapies impair patients' quality of life and are often inadequate. Therefore,
developing alternative therapies and new drugs has become increasingly
important. This study investigated the effect of the curcumin analog EF-24 on
prostate cancer cells. A comprehensive cytotoxicity analysis was performed with
PNT1A normal prostate cells and DU145 and PC3, two different metastatic
prostate cancer cell lines. In addition, a two-dimensional migration assay and
qRT-PCR method were used to identify the impact of EF-24 on the metastatic
mechanism of prostate cancer. EF-24 was found to be specifically cytotoxic to
prostate cancer cells at low doses. In addition, EF-24 inhibits the metastatic mechanism,
probably by increasing E-cadherin. Natural components are coming to the fore in
cancer drug research. Curcumin has been used in various fields, and its effect
on various cancers has been shown in vitro and in vivo studies. Due to the low
bioavailability of curcumin, various analogs have been developed and EF-24 is
one of the best known of these analogs. Its effect on various types of cancer
has been studied and it is considered a potential drug. The results we obtained
are consistent with those found in the literature. In conclusion, EF-24
inhibits the proliferation and migration of prostate cancer cells. Although the
results obtained in our study show the potential of EF-24 in the therapy of
prostate cancer, it needs to be supported by extensive molecular research and
in vivo experiments.