Synthesis, microwave-promoted catalytic activity in Suzuki-Miyaura cross-coupling reactions and antimicrobial properties of novel benzimidazole salts bearing trimethylsilyl group
Applied Organometallic Chemistry, cilt.25, sa.5, ss.366-373, 2011 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 25 Sayı: 5
- Basım Tarihi: 2011
- Doi Numarası: 10.1002/aoc.1772
- Dergi Adı: Applied Organometallic Chemistry
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.366-373
- Anahtar Kelimeler: antimicrobial activity., benzimidazole salt, carbene, coupling reaction, microwave, palladium catalysis, Suzuki-Miyaura coupling
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
A mixture of benzimidazole salts (2-7), Pd(OAc)2 and K 2CO3 in DMF-H2O catalyzes the Suzuki-Miyaura cross-coupling reactions promoted by microwave irradiation resulting in high yield within a short time. In particular, the yield of the Suzuki-Miyaura reactions with aryl bromides was found to be nearly quantitative. The synthesized benzimidazole salts (2-7) were identified by 1H- 13C, NMR, IR spectroscopic methods and microanalysis. The molecular structure of 1 was determined by X-ray crystallography. The antibacterial and antifungal activities of the novel benzimidazole derivatives (1-7) were also tested against standard strains. © 2011 John Wiley & Sons, Ltd.