Thiol/disulfide homeostasis in postmenopausal osteoporosis
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION, cilt.40, sa.4, ss.431-435, 2017 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 40 Sayı: 4
- Basım Tarihi: 2017
- Doi Numarası: 10.1007/s40618-016-0585-7
- Dergi Adı: JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.431-435
- Anahtar Kelimeler: Disulfide, Postmenopausal osteoporosis, Thiol
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Evet
Özet
Aim: To evaluate the impact of postmenopausal osteoporosis on thiol/disulfide homeostasis. Materials and methods: A total of 75 participants were divided into two groups: Group 1 (n = 40) was composed of healthy postmenopausal women, and group 2 (n = 35) was composed of women with postmenopausal osteoporosis. Clinical findings and thiol/disulfide homeostasis were compared between the two groups. Results: The disulfide/native thiol ratio was 8.6% ± 3.6 in group 1 and 12.7% ± 8.4 in group 2 (p = 0.04). The disulfide/native thiol percent ratio was significantly higher in group 2 after adjustment for the years since menopause and age (p < 0.05). The native thiol/total thiol percent ratio was 85.6% ± 4.8 in group 1 and 73.8% ± 24.9 in group 2 (p = 0.01). The native thiol/total thiol percent ratio was significantly lower in group 2 after adjustment for the years since menopause and age (p < 0.05). Conclusion: Thiol/disulfide homeostasis shifted to the disulfide side independent of age and years since menopause in postmenopausal osteoporosis.