Abnormal Circadian Blood Pressure Regulation in Children Born Preterm
Journal of Pediatrics, cilt.151, sa.4, ss.399-403, 2007 (SCI-Expanded, Scopus)
- Yayın Türü: Makale / Tam Makale
- Cilt numarası: 151 Sayı: 4
- Basım Tarihi: 2007
- Doi Numarası: 10.1016/j.jpeds.2007.04.003
- Dergi Adı: Journal of Pediatrics
- Derginin Tarandığı İndeksler: Science Citation Index Expanded (SCI-EXPANDED), Scopus
- Sayfa Sayıları: ss.399-403
- Ankara Yıldırım Beyazıt Üniversitesi Adresli: Hayır
Özet
Objective: To assess a possible relationship between prematurity and casual blood pressure (BP) by means of 24-hour ambulatory BP monitoring (ABPM). Study design: ABPM was performed in 41 children aged 5 to 17 years who were born prematurely with (n = 11) or without intrauterine growth restriction, and in 27 matched children who were born at term with a birth weight appropriate for gestational age. Results: Although BP did not differ between the preterm group and control subjects during the daytime, nocturnal standardized systolic BP was elevated (P < .05) and a lack of nocturnal decrease was more prevalent in the preterm children compared with the control subjects (73% versus 41%, P = .01). The difference was caused by a marked increase of nighttime systolic BP in the light-for-date children (1.17 ± 0.61 standard deviation scores; P < .01), although preterm children with appropriate weight (0.33 ± 1.00) were not different from control subjects (0.09 ± 0.73). Nighttime BP standard deviation scores were closely correlated with standardized heart rate, compatible with a role of sympathetic hyperactivation. Conclusion: Subtle abnormalities of BP regulation, indicated by a selective increase of nocturnal systolic BP, are present during childhood in subjects born prematurely, and are prominent in those with intrauterine growth restriction. © 2007 Mosby, Inc. All rights reserved.