Research Information System
Turkish Journal of Gastroenterology, vol.29, no.3, pp.348-353, 2018 (SCI-Expanded, Scopus, TRDizin)
Background/Aims: The dynamic thiol/disulfide homeostasis plays pivotal roles in many physiological mechanisms in an organism. We aimed to investigate whether dynamic thiol/disulfide homeostasis changes among patients with acute pancreatitis.Materials and Methods: This prospective trial contained 45 patients with acute pancreatitis and 45 sex-and age-matched healthy vol-unteers as control group. Thiol/disulfide homeostasis parameters were measured by a novel and automated assay, and detected results were compared between the two groups.Results: Disulfide/total thiol percent ratio and disulfide/native thiol percent ratios were significantly higher in acute pancreatitis group;besides the native thiol, total thiol levels and native thiol/total thiol percent ratios were significantly lower (for all p<0.001). Conclusion: The thiol/disulfide homeostasis is impaired in acute pancreatitis with a shift toward the oxidative status, and this deficiency might be a pathogenic factor in acute pancreatitis. The correction of this thiol/disulfide imbalance may be a new target in the manage-ment of acute pancreatitis.